Reply to “The Brain, Amphotericin B, and P-Glycoprotein”
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منابع مشابه
Reply to "the brain, amphotericin B, and p-glycoprotein".
We thank David A. Stevens et al. (1) for the letter suggesting different results regarding the effect of P-glycoprotein on the brain concentration of amphotericin B (AMB) by P-glycoprotein knockout mice. In contrast to our finding that blockage of P-glycoprotein with inhibitors enhances the brain uptake of AMB (2), they found that brain AMB concentrations were significantly lower in Mdr1a/1b / ...
متن کاملThe brain, amphotericin B, and P-glycoprotein.
We read with interest the paper by Wu et al. (1) purporting to show that blockade of P-glycoprotein with verapamil or itraconazole increased brain concentrations of amphotericin B (AMB). Because virtually all P-glycoprotein blockers also block other transporters, we chose to compare P-glycoprotein knockout (KO) mice (Mdr1a/1b) with isogenic FVB wild-type mice. After administration of intravenou...
متن کاملIn vitro and in vivo evidence for amphotericin B as a P-glycoprotein substrate on the blood-brain barrier.
Amphotericin B (AMB) has been a mainstay therapy for fungal infections of the central nervous system, but its use has been limited by its poor penetration into the brain, the mechanism of which remains unclear. In this study, we aimed to investigate the role of P-glycoprotein (P-gp) in AMB crossing the blood-brain barrier (BBB). The uptake of AMB by primary brain capillary endothelial cells in ...
متن کاملComparative susceptibility of four kinds of pathogenic fungi to amphotericin B and amphotericin B methyl ester.
The activity of amphotericin B methyl ester was compared with that of amphotericin B, using Candida albicans (34 isolates), Torulopsis glabrata (12 isolates), Filobasidiella neoformans (stat. conid. Cryptococcus neoformans) (14 isolates), and Coccidioides immitis (37 isolates) and tube dilution in a totally synthetic, completely defined medium (SAAMF) with inocula of 10(4) colony-forming units ...
متن کاملAn Amphotericin B Derivative Equally Potent to Amphotericin B and with Increased Safety
Amphotericin B is the most potent antimycotic known to date. However due to its large collateral toxicity, its use, although long standing, had been limited. Many attempts have been made to produce derivatives with reduced collateral damage. The molecular mechanism of polyene has also been closely studied for this purpose and understanding it would contribute to the development of safe derivati...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2015
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.04774-14